Tesamorlin

Tesamorelin is a synthetic analog of growth hormone-releasing hormone (GHRH) that stimulates the pituitary gland to produce more endogenous growth hormone and IGF-1. It is primarily prescribed to reduce visceral adipose tissue (deep belly fat) in adults with HIV-associated lipodystrophy. Unlike direct growth hormone therapy, tesamorelin works by enhancing the body’s own physiologic GH secretion. Research has shown it can significantly reduce abdominal visceral fat while helping preserve lean muscle mass. Outside its FDA-approved use, it is sometimes discussed off-label for metabolic health, body composition, and anti-aging purposes, although these uses are not FDA-approved. Common side effects may include injection-site reactions, swelling, joint pain, and changes in glucose metabolism.